Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916349" target="_blank" >RIV/00216208:11120/18:43916349 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jns.2018.02.026" target="_blank" >https://doi.org/10.1016/j.jns.2018.02.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2018.02.026" target="_blank" >10.1016/j.jns.2018.02.026</a>

Result language

angličtina

Original language name

Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Original language description

Background: The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS. Objective: To investigate the relationship between the subjective impact of fatigue and objective walking capacity as well as subjective walking ability in MS patients. Methods: A cross-sectional multicenter study design was applied. Ambulatory MS patients (n = 189, age: 47.6 +- 10.5 years; gender: 115/74 women/men; Expanded Disability Status Scale (EDSS): 4.1 +- 1.8 [range: 0-6.5]) were tested at 11 sites. Objective tests of walking capacity included short walking tests (Timed 25-Foot Walk (T25FW), 10-Metre Walk Test (10mWT) at usual and fastest speed and the timed up and go (TUG)), and long walking tests (2- and 6-Minute Walk Tests (MWT). Subjective walking ability was tested applying the Multiple Sclerosis Walking Scale-12 (MSWS-12). Fatigue impact was measured by the self-reported modified fatigue impact scale (MFIS) consisting of a total score (MFIStotal) and three subscales (MFISphysical, MFIScognitive and MFISpsychosocial). Uni- and multivariate regression analysis were performed to evaluate the relation between walking and fatigue impact. Results: MFIStotal was negatively related with long (6MWT, r = MINUS SIGN 0.14, p = 0.05) and short composite (TUG, r = MINUS SIGN 0.22, p = 0.003) walking measures. MFISphysical showed a significant albeit weak relationship to walking speed in all walking capacity tests (r = MINUS SIGN 0.22 to MINUS SIGN 0.33, p &lt;.0001), which persisted in the multivariate linear regression analysis. Subjective walking ability (MSWS-12) was related to MFIStotal (r = 0.49, p &lt; 0.0001), as well as to all other subscales of MFIS (r = 0.24-0.63, p &lt; 0.001), showing stronger relationships than objective measures of walking. Conclusions: The physical impact of fatigue is weakly related to objective walking capacity, while general, physical, cognitive and psychosocial fatigue impact are weakly to moderately related to subjective walking ability, when analysed in a large heterogeneous sample of MS patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Volume of the periodical

387

Issue of the periodical within the volume

April

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

179-186

UT code for WoS article

000430775700034

EID of the result in the Scopus database

2-s2.0-85042425183