Secondary central nervous system lymphoma: spectrum of morphological MRI appearances

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916536" target="_blank" >RIV/00216208:11120/18:43916536 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/18:10375338 RIV/00064173:_____/18:N0000099 RIV/00023884:_____/18:00007521

Result on the web

<a href="https://doi.org/10.2147/NDT.S157959" target="_blank" >https://doi.org/10.2147/NDT.S157959</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S157959" target="_blank" >10.2147/NDT.S157959</a>

Result language

angličtina

Original language name

Secondary central nervous system lymphoma: spectrum of morphological MRI appearances

Original language description

Background: Secondary central nervous system lymphoma (SCNSL) is a rare and aggressive disease, which is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. According to previous reports, SCNSL presents mostly with leptomeningeal spread; however, our experience differs. In the present study, we demonstrate the diversity of magnetic resonance imaging (MRI) patterns in SCNSL. Patients and methods: Initial morphological MRI findings in 21 patients (10 women and 11 men with mean age 62.3+-16.2 years) with SCNSL were retrospectively evaluated. All patients suffered from neurological symptoms and underwent MRI, and all cases were histologically verified. Twelve patients were treated by corticosteroids at the time of the initial MRI. Results: Parenchymal lesions were present in 18 of 21 cases (85.7%), solitary meningeal infiltration was present in 1 patient (4.8%), leptomeningeal infiltration in combination with hypophyseal involvement in 1 patient (4.8%), and solitary involvement of the sixth cranial nerve (CN) was found in 1 patient (4.8%). Multiple lesions were present in 11 of 21 cases (52.4%). Diffusion restriction in all or part of the lesion was detected in 14 of 18 cases (77.8%). All parenchymal lesions had an infiltrative appearance and most enhanced homogenously (11 of 17 cases; 64.7%). A combination of parenchymal and meningeal involvement was found in 10 of 21 cases (47.6%). Infiltration of the CNs, basal ganglia, corpus callosum, and ependyma was present in 8 of 21 cases (38.1%) for each of the abovementioned structures; hypothalamic-hypophyseal axis was affected in 7 of 21 cases (33.3%). Conclusion: In contrast to previous reports, SCNSL presented as parenchymal disease. MRI is not sufficient for differentiation between primary and secondary CNS lymphoma.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

1178-2021

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

January

Country of publishing house

NZ - NEW ZEALAND

Number of pages

8

Pages from-to

733-740

UT code for WoS article

000427370300001

EID of the result in the Scopus database

2-s2.0-85053768869