Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916553" target="_blank" >RIV/00216208:11120/18:43916553 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/18:N0000036

Result on the web

<a href="https://doi.org/10.1111/cen.13600" target="_blank" >https://doi.org/10.1111/cen.13600</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cen.13600" target="_blank" >10.1111/cen.13600</a>

Result language

angličtina

Original language name

Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN

Original language description

OBJECTIVE: Hypercortisolism in Cushing&apos;s syndrome (CS) is associated with impaired Health-Related Quality of Life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing&apos;s syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment, than patients with adrenal causes (ADR-CS). METHODS: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analyzed. RESULTS: At baseline, HRQoL did not differ between PIT-CS (n=293) and ADR-CS (n=120) on both EuroQoL or CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41+-18 and 44+-20, respectively (P=0.7). At long-time follow-up (&gt;1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56+-20 vs. 62+-23; P=0.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P &lt;0.001), and older age at diagnosis with worse total score (P = 0.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P &lt;0.001). CONCLUSION: PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no inter-etiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Endocrinology

ISSN

0300-0664

e-ISSN

—

Volume of the periodical

88

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

787-798

UT code for WoS article

000434078900005

EID of the result in the Scopus database

2-s2.0-85045415624