Conservative management of endometrial cancer: a survey amongst European clinicians
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916890" target="_blank" >RIV/00216208:11120/18:43916890 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/18:N0000091
Result on the web
<a href="https://doi.org/10.1007/s00404-018-4820-7" target="_blank" >https://doi.org/10.1007/s00404-018-4820-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00404-018-4820-7" target="_blank" >10.1007/s00404-018-4820-7</a>
Alternative languages
Result language
angličtina
Original language name
Conservative management of endometrial cancer: a survey amongst European clinicians
Original language description
Objective: To investigate differences and similarities in the clinical approach of young clinicians managing women with endometrial cancer (EC) conservatively. Methods: A web-based survey was carried out. A platform of the European Network of Young Gynaecological Oncologists (ENYGO) database was used. A 38-item multiple-choice questionnaire was used to evaluate current practice in fertility-sparing management of EC. The survey covered investigations, treatment options, follow-up and management of recurrence and future family planning. Descriptive statistics were used. Results: Overall, 116 out of 650 (17.84%) ENYGO members responded to the survey. In 92 (79.3%) centres, the caseload of early stage EC treated conservatively was less than 10 per year. One hundred and seven responders (93.8%) believe that treatment with progestins could be offered in grade 1 EC without myometrial invasion, but a minority would recommend it even for grade 2 tumours with no myometrial invasion or grade 1 with superficial invasion. The diagnostic tool for establishing grade of tumour was hysteroscopy with dilatation and curettage in 64 (55%) centres. Medroxyprogesterone acetate represents the most commonly prescribed progestogen (55, 47.4%). In 78 (67.2%) centres, a repeat endometrial biopsy was offered after 3 months of treatment commencement. Recurrences are treated mostly with hysterectomy (81, 69.9%) with only a small number of responders recommending to repeat progestin treatment. Lynch syndrome is a contraindication for conservative management in half of the responders (57, 49.1%). Most clinicians agree that patients should be referred promptly for assisted reproductive techniques once complete response has been achieved (68, 58.6%). Conclusions: Our study shows that conservative management is increasingly offered to women affected by early stage EC wishing to preserve their fertility. Further studies and joint registries are required to evaluate safety and effectiveness of this approach in this probably growing number of patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Gynecology and Obstetrics
ISSN
0932-0067
e-ISSN
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Volume of the periodical
298
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
373-380
UT code for WoS article
000438090000016
EID of the result in the Scopus database
2-s2.0-85049111053