Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916924" target="_blank" >RIV/00216208:11120/18:43916924 - isvavai.cz</a>

Alternative codes found

RIV/00023698:_____/18:N0000007

Result on the web

<a href="https://doi.org/10.1002/term.2734" target="_blank" >https://doi.org/10.1002/term.2734</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/term.2734" target="_blank" >10.1002/term.2734</a>

Result language

angličtina

Original language name

Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Original language description

Gore-Tex(R) is a widely used durable patch for repair of congenital diaphragmatic defects yet may result in complications. We compared Gore-Tex to a composite of a radial pore orientated collagen scaffold (RP-Composite) and clinically used porcine small intestinal submucosa (SIS; Surgisis(R)) in a rabbit model for diaphragmatic hernia. The growing rabbit mimics the rapid rib cage growth and re-herniation rates seen in children. We created and immediately repaired left hemi-diaphragmatic defects in 6-week-old rabbits with Gore-Tex, SIS and a RP-Composite scaffold. An additional group of rabbits had a sham operation. At 90 days, survivors more than doubled in weight. We observed few re-herniations or eventrations in Gore-Tex (17%) and RP-Composite (22%) implanted animals. However, SIS failed in all rabbits. Maximum transdiaphragmatic pressure was lower in Gore-Tex (71%) than RP-Composite implanted animals (112%) or sham (134%). Gore-Tex repairs were less compliant than RP-Composite, which behaved as sham diaphragm (p&lt;0.01). RP-Composite induced less foreign body giant cell reaction than Gore-Tex (p&lt;0.05) with more collagen deposition (p&lt;0.001), although there was a tendency for the scaffold to calcify. Unlike Gore-Tex, the compliance of diaphragms reconstructed with RP-Composite scaffolds were comparable to native diaphragm, whereas re-herniation rates and transdiaphragmatic pressure measurements were similar.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Tissue Engineering and Regenerative Medicine

ISSN

1932-6254

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

2138-2150

UT code for WoS article

000450014700002

EID of the result in the Scopus database

2-s2.0-85053425877