Early Postnatal Stress Impairs Cognitive Functions of Male Rats Persisting until Adulthood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916987" target="_blank" >RIV/00216208:11120/18:43916987 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3389/fnbeh.2018.00176" target="_blank" >https://doi.org/10.3389/fnbeh.2018.00176</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnbeh.2018.00176" target="_blank" >10.3389/fnbeh.2018.00176</a>

Result language

angličtina

Original language name

Early Postnatal Stress Impairs Cognitive Functions of Male Rats Persisting until Adulthood

Original language description

Methamphetamine (MA) is the most abused &quot;hard&quot; illicit drug in the Czech Republic. Drugs abused during pregnancy are not hazardous merely to the mother, but also to developing fetuses. The offspring of drug-addicted mothers are also often exposed to perinatal stressors that may impair brain development of affected progeny. The present study examines the effect of perinatal stressors and drug exposure on cognitive function in male progeny. In the present study, rat mothers were divided into three groups according to drug treatment during pregnancy: controls (C); saline (SA, s.c., 1 ml/kg); MA (s.c., 5 mg/ml/kg). Litters were divided into two groups according to postnatal stressors: non-stressed controls (N); Maternal separation (MS). For evaluation of learning and memory, adult male progeny were tested in the Morris Water Maze (MWM). Our results revealed no significant effects caused by prenatal drug or prenatal stress exposure. On the other hand, chronic postnatal stress, mediated by MS, significantly impaired learning on the Place Navigation test. In addition, MS was associated with changes in search strategies on the Place Navigation, Probe, and Memory Recall tests. Specifically, postnatal stress increased thigmotaxis, indicating less awareness of the hidden platform. In conclusion, the present study provides evidence that exposure to early postnatal stress significantly impairs cognitive functions of male rats, which persists into adulthood.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA18-03806S" target="_blank" >GA18-03806S: Impact of different environments on cognitive functions of adolescent male rats exposed prenatally to methamphetamine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Behavioral Neuroscience

ISSN

1662-5153

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

August

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

"Article 176"

UT code for WoS article

000441918400001

EID of the result in the Scopus database

2-s2.0-85053302683