Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F19%3A43919417" target="_blank" >RIV/00216208:11120/19:43919417 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1038/s42255-018-0007-6" target="_blank" >https://doi.org/10.1038/s42255-018-0007-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s42255-018-0007-6" target="_blank" >10.1038/s42255-018-0007-6</a>

Result language

angličtina

Original language name

Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity

Original language description

Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive transcription factor ChREBP and its target, the fatty acid elongase ELOVL6. Genetic inhibition of HSL in human adipocytes and mouse adipose tissue results in enhanced insulin sensitivity and induction of ELOVL6. ELOVL6 promotes an increase in phospholipid oleic acid, which modifies plasma membrane fluidity and enhances insulin signalling. HSL deficiency-mediated effects are suppressed by gene silencing of ChREBP and ELOVL6. Mechanistically, physical interaction between HSL, independent of lipase activity, and the isoform activated by glucose metabolism ChREBP alpha impairs ChREBP alpha translocation into the nucleus and induction of ChREBP beta, the isoform with high transcriptional activity that is strongly associated with whole-body insulin sensitivity. Targeting the HSL-ChREBP interaction may allow therapeutic strategies for the restoration of insulin sensitivity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Metabolism

ISSN

2522-5812

e-ISSN

—

Volume of the periodical

1

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

133-146

UT code for WoS article

000500725600017

EID of the result in the Scopus database

2-s2.0-85058842115