Retinoic acid grafted to hyaluronan for skin delivery: Synthesis, stability studies, and biological evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919429" target="_blank" >RIV/00216208:11120/20:43919429 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.carbpol.2019.115733" target="_blank" >https://doi.org/10.1016/j.carbpol.2019.115733</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2019.115733" target="_blank" >10.1016/j.carbpol.2019.115733</a>
Alternative languages
Result language
angličtina
Original language name
Retinoic acid grafted to hyaluronan for skin delivery: Synthesis, stability studies, and biological evaluation
Original language description
All-trans retinoic acid (ATRA) was grafted to hyaluronan (HA) via esterification. The reaction was mediated by mixed anhydrides. A perfect control of the degree of substitution (0.5-7.5%) was obtained by varying the molar ratio of retinoic acid in the feed. The degree of substitution plays a significant role in the long-term stability. The photodegradation of HA-ATRA upon UVA irradiation resulted in β-ionone, β-cyclocitral and 5,6-epoxy-(E)-retinoic acid. The photostability of the conjugate had increased with the combination with morin. The chemical structure of HA-ATRA and its degradation products was elucidated using NMR spectroscopy, SEC-MALLS, and gas chromatography-mass spectrometry (GC-MS). ATRA did not loss its biological activity after conjugation, as demonstrated by gene expression. The derivative was able to penetrate across the stratum corneum. Besides, HA-ATRA downregulated the expression of anti-inflammatory interleukins 6 and 8. HA-ATRA would be expected to be used for transdermal drug delivery or cosmetics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30216 - Dermatology and venereal diseases
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Polymers
ISSN
0144-8617
e-ISSN
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Volume of the periodical
231
Issue of the periodical within the volume
March
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"Article 115733"
UT code for WoS article
000504650500046
EID of the result in the Scopus database
2-s2.0-85076248044