Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919917" target="_blank" >RIV/00216208:11120/20:43919917 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/20:N0000047
Result on the web
<a href="https://doi.org/10.1038/s41366-020-0559-x" target="_blank" >https://doi.org/10.1038/s41366-020-0559-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41366-020-0559-x" target="_blank" >10.1038/s41366-020-0559-x</a>

Result language
angličtina
Original language name
Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women
Original language description
It has been shown that many molecules released by adipose tissue (AT) into interstitial fluid can reach the bloodstream preferentially via lymphatic system. Worsened lymphatic drainage may alter interstitial fluid (ISF) composition and thus affect microenvironment of adipocytes. Nevertheless, the effect of lymphatic drainage on AT functions remains unknown. Therefore, we analyzed the lipolytic activity of femoral AT in two groups of premenopausal women similar in adiposity but differing in the efficiency of lymphatic drainage of lower body as assessed by lymphoscintigraphy. Levels of lipolytic markers were assessed in plasma and ISF collected by skin blister technique in femoral area. In addition, microdialysis was used to monitor lipolysis of AT in vivo. Our results indicate that worsened lymphatic drainage is associated with lower in vivo lipolytic index and reduced lipolytic responsiveness of femoral AT to adrenergic stimuli. Thus, efficiency of lymphatic drainage appears to play a role in the regulation of AT metabolism. Accordingly, worsened lymphatic drainage could contribute to the resistance of lower body AT to intentional weigh loss.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/GA16-00477S" target="_blank" >GA16-00477S: LYMPHAT- Lymphatic stasis as a modulator of adipose tissue expansion and inflammation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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