Spontaneous delivery is associated with increased endothelial activity in cord blood compared to elective cesarean section
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920240" target="_blank" >RIV/00216208:11120/20:43920240 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10411859 RIV/00064203:_____/20:10411859 RIV/00064190:_____/20:N0000009 RIV/00023001:_____/20:00080247 and 2 more
Result on the web
<a href="https://doi.org/10.1016/j.ejogrb.2020.05.059" target="_blank" >https://doi.org/10.1016/j.ejogrb.2020.05.059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejogrb.2020.05.059" target="_blank" >10.1016/j.ejogrb.2020.05.059</a>
Alternative languages
Result language
angličtina
Original language name
Spontaneous delivery is associated with increased endothelial activity in cord blood compared to elective cesarean section
Original language description
Objectives: It is suggested that delivery whether spontaneous or by elective cesarean section is associated with an inflammatory reaction which may be modified by the type of delivery. Inflammatory reactions are associated with endothelial activation. The aim of our study was to assess endothelial biomarkers in cord and neonatal blood following different modes of delivery. Study design: The study group consisted of term healthy newborns after uncomplicated pregnancies and either spontaneous vaginal delivery (n = 39) or elective cesarean section (n = 20). Plasma soluble biomarkers were measured using multiplex magnetic bead immunoassay. The microvesicle count and number of surface antigen-specific microvesicles were determined by flow cytometry. Results: We found significantly increased concentrations of cord blood endothelial markers (sVEGFR1, Endothelin-1 and sVCAM1) and microvesicles (EPCR/CD201+, ICAM1/CD54+ and PECAM1/CD31+) in spontaneous vaginal delivery when compared to elective cesarean section. Irrespective of the delivery mode endothelial markers sVEGFR1, Endocan, Angiopoietin-2, VEGF, and sICAM1, were significantly increased in neonatal compared to cord blood. Conclusion: We found increased cord blood concentrations of endothelial markers and microvesicles following spontaneous vaginal delivery, which may reflect the natural activation of endothelial cells during labor. Following the delivery, most of the soluble markers increased, as a possible consequence of activation of neonatal innate immunity and postnatal cardiovascular transition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Obstetrics & Gynecology and Reproductive Biology
ISSN
0301-2115
e-ISSN
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Volume of the periodical
251
Issue of the periodical within the volume
August
Country of publishing house
IE - IRELAND
Number of pages
6
Pages from-to
229-234
UT code for WoS article
000573041500038
EID of the result in the Scopus database
2-s2.0-85086338642