Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920289" target="_blank" >RIV/00216208:11120/20:43920289 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.4103/CJP.CJP_10_20" target="_blank" >https://doi.org/10.4103/CJP.CJP_10_20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4103/CJP.CJP_10_20" target="_blank" >10.4103/CJP.CJP_10_20</a>
Alternative languages
Result language
angličtina
Original language name
Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review
Original language description
Alzheimer's disease is a major health problem all over the world. The role of beta-amyloid (Aβ) is at the center of investigations trying to discover the disease pathogenesis and to develop drugs for treatment or prevention on Alzheimer's disease. This review summarizes both physiological and pathological functions of Aβ and factors that may participate in the disease development. Known genetic factors are trisomy of chromosome 21, mutations of presenilin 1 and 2, and apolipoprotein E4. Lifetime stresses that increase the risk of development of Alzheimer's disease are described. Another important factor is the level of education, especially of linguistic ability. Lifestyle factors include mental and physical exercise, head injury, social contacts, and diet. All these factors might potentiate the effect of aging on the brain to increase the risk of development of pathological changes. The review summarizes pathological features of Alzheimer brain, Aβ plaques, neurofibrillary tangles composed of hyperphosphorylated tau, and brain atrophy. Consequences of Alzheimer's disease that are reviewed include cognitive deficit, loss of function, and neuropsychiatric symptoms. Because there is no effective treatment, many persons with Alzheimer's disease survive to severe and terminal stages which they may fear. Alzheimer's disease at this stage should be considered a terminal disease for which palliative care is indicated. Importance of advance directives, promoting previous wishes of the person who was developing dementia and who subsequently lost decision-making capacity, and limitations of these directives are discussed. Information in this review is based on author's knowledge and clinical experience that were updated by searches of PubMed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chinese Journal of Physiology
ISSN
0304-4920
e-ISSN
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Volume of the periodical
63
Issue of the periodical within the volume
3
Country of publishing house
IN - INDIA
Number of pages
6
Pages from-to
95-100
UT code for WoS article
000546028300001
EID of the result in the Scopus database
2-s2.0-85087253955