Functional electrical stimulation-assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921430" target="_blank" >RIV/00216208:11120/21:43921430 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/21:N0000055

Result on the web

<a href="https://doi.org/10.1136/thoraxjnl-2020-215755" target="_blank" >https://doi.org/10.1136/thoraxjnl-2020-215755</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/thoraxjnl-2020-215755" target="_blank" >10.1136/thoraxjnl-2020-215755</a>

Result language

angličtina

Original language name

Functional electrical stimulation-assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up

Original language description

Purpose: Functional electrical stimulation-assisted cycle ergometry (FESCE) enables in-bed leg exercise independently of patients&apos; volition. We hypothesised that early use of FESCE-based progressive mobility programme improves physical function in survivors of critical care after 6 months. Methods: We enrolled mechanically ventilated adults estimated to need &gt;7 days of intensive care unit (ICU) stay into an assessor-blinded single centre randomised controlled trial to receive either FESCE-based protocolised or standard rehabilitation that continued up to day 28 or ICU discharge. Results: We randomised in 1:1 ratio 150 patients (age 61+-15 years, Acute Physiology and Chronic Health Evaluation II 21+-7) at a median of 21 (IQR 19-43) hours after admission to ICU. Mean rehabilitation duration of rehabilitation delivered to intervention versus control group was 82 (IQR 66-97) versus 53 (IQR 50-57) min per treatment day, p&lt;0.001. At 6 months 42 (56%) and 46 (61%) patients in interventional and control groups, respectively, were alive and available to follow-up (81.5% of prespecified sample size). Their Physical Component Summary of SF-36 (primary outcome) was not different at 6 months (50 (IQR 21-69) vs 49 (IQR 26-77); p=0.26). At ICU discharge, there were no differences in the ICU length of stay, functional performance, rectus femoris cross-sectional diameter or muscle power despite the daily nitrogen balance was being 0.6 (95% CI 0.2 to 1.0; p=0.004) gN/m2 less negative in the intervention group. Conclusion: Early delivery of FESCE-based protocolised rehabilitation to ICU patients does not improve physical functioning at 6 months in survivors. Trial registration number: NCT02864745.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30221 - Critical care medicine and Emergency medicine

Project

<a href="/en/project/NV16-28663A" target="_blank" >NV16-28663A: Functional electrical stimulation-assisted cycle ergometry in critically ill: Linking deranged muscle physiology to long-term functional outcome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thorax

ISSN

0040-6376

e-ISSN

—

Volume of the periodical

76

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

664-671

UT code for WoS article

000667291900009

EID of the result in the Scopus database

2-s2.0-85105191148