The Efficacy and Safety of Hybrid Ablations for Atrial Fibrillation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921768" target="_blank" >RIV/00216208:11120/21:43921768 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11210/21:10429105 RIV/00064173:_____/21:N0000022

Result on the web

<a href="https://doi.org/10.1016/j.jacep.2021.04.013" target="_blank" >https://doi.org/10.1016/j.jacep.2021.04.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacep.2021.04.013" target="_blank" >10.1016/j.jacep.2021.04.013</a>

Result language

angličtina

Original language name

The Efficacy and Safety of Hybrid Ablations for Atrial Fibrillation

Original language description

OBJECTIVES: This study sought to comprehensively determine the procedural safety and midterm efficacy of hybrid ablations. BACKGROUND: Hybrid ablation of atrial fibrillation (AF) (thoracoscopic ablation followed by catheter ablation) has been used for patients with nonparoxysmal AF; however, accurate data regarding efficacy and safety are still limited. METHODS: Patients with nonparoxysmal AF underwent thoracoscopic, off-pump ablation using the COBRA Fusion radiofrequency system (Estech) followed by a catheter ablation 3 months afterward. The safety of the procedure was assessed using sequential brain magnetic resonance and neuropsychological examinations at baseline (1 day before), postoperatively (2-4 days for brain magnetic resonance imaging or 1 month for neuropsychological examination), and at 9 months after the surgical procedure. Implantable loop recorders were used to detect arrhythmia recurrence. Arrhythmia-free survival (the primary efficacy endpoint) was defined as no episodes of AF or atrial tachycardia while off antiarrhythmic drugs, redo ablations or cardioversions. RESULTS: Fifty-nine patients (age: 62.5 +- 10.5 years) were enrolled, 37 (62.7%) were men, and the mean follow-up was 30.3 +- 10.8 months. Thoracoscopic ablation was successfully performed in 55 (93.2%) patients. On baseline magnetic resonance imaging, chronic ischemic brain lesions were present in 60% of patients. New ischemic lesions on postoperative magnetic resonance imaging were present in 44.4%. Major postoperative cognitive dysfunction was present in 27.0% and 17.6% at 1 and 9 months postoperatively, respectively. The probability of arrhythmia-free survival was 54.0% (95% CI: 41.3-66.8) at 1 year and 43.8% (95% CI: 30.7-57.0) at 2 years. CONCLUSIONS: The thoracoscopic ablation is associated with a high risk of silent cerebral ischemia. The midterm efficacy of hybrid ablations is moderate.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV16-32478A" target="_blank" >NV16-32478A: EndoMaze HYBRID project-a detailed assessment of efficacy and safety of hybrid ablation of persistent and long-standing persistent atrial fibrillation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JACC: Clinical Electrophysiology

ISSN

2405-500X

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1519-1529

UT code for WoS article

000744196000008

EID of the result in the Scopus database

2-s2.0-85121001357