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Failure of Warfarin Anticoagulation Therapy after Administration of Oral Terbinafine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921817" target="_blank" >RIV/00216208:11120/21:43921817 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.14712/18059694.2021.23" target="_blank" >https://doi.org/10.14712/18059694.2021.23</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14712/18059694.2021.23" target="_blank" >10.14712/18059694.2021.23</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Failure of Warfarin Anticoagulation Therapy after Administration of Oral Terbinafine

  • Original language description

    Warfarin is widely used anticoagulant drug for a variety of diseases (thromboembolic disease, atrial fibrillation, etc.). It has three most important parallel metabolic pathways, CYP1A2, CYP3A4 and CYP2C9. Terbinafine is a potent CYP2D6 inhibitor. A possible drug interaction could lead to an increased pharmacological effect of the above drugs. Enzyme induction with CYP3A4, CYP2C9, CYP1A2 inducers may have occurred. Case report: We present a case report of an 88-year-old male patient who has been successfully anticoagulated with warfarin due to atrial fibrillation. He was orally administered terbinafine to treat onychomycosis. Two weeks after initiation of this drug the patient experienced dizziness and feelings of instability, for which he was admitted to the neurology department. A low-efficient INR level was found at the baseline, presumably due to warfarin interaction with terbinafine. The induction of liver enzymes lasts 10-14 days, which matches the introduction of the antifungal agent. Conclusion: Combined therapy with warfarin and oral terbinafine is actually rarely prescribed but, if used, their interaction can have serious consequences in many clinical situations for which anticoagulation therapy with warfarin is indicated.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Medica

  • ISSN

    1211-4286

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    4

  • Pages from-to

    132-135

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85113274003