Late Radiation-Related Toxicities in Patients Treated for Early-Stage Cervical Carcinoma by Surgery and Adjuvant Radiotherapy: A Retrospective Imaging Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43922419" target="_blank" >RIV/00216208:11120/21:43922419 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/21:10432781 RIV/00064173:_____/21:N0000011 RIV/00064173:_____/21:N0000021

Result on the web

<a href="https://doi.org/10.3389/pore.2021.1609915" target="_blank" >https://doi.org/10.3389/pore.2021.1609915</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/pore.2021.1609915" target="_blank" >10.3389/pore.2021.1609915</a>

Result language

angličtina

Original language name

Late Radiation-Related Toxicities in Patients Treated for Early-Stage Cervical Carcinoma by Surgery and Adjuvant Radiotherapy: A Retrospective Imaging Study

Original language description

Surgical treatment is preferred therapy of early-stage cervical carcinoma. In the risk of cancer recurrence surgery is often followed by adjuvant radiotherapy. In our retrospective study we aimed at identifying late (&gt;=6 months) and very late (&gt;=5 years) radiation adverse effects on imaging scans as CT, PET/CT and MRI in patients who underwent successful treatment for cervical carcinoma by radical surgery combined with radiotherapy +- chemotherapy. We correlated imaging results with clinical manifestations. We selected young and middle-aged patients with long life expectancy, as late radiation-related toxicities may significantly affect their quality of life. Patients were selected from those who were primary diagnosed and treated between the years 1987-2011 and regularly visited our Oncology department in years 2011-2012. Following inclusion criteria were applied: age &lt;=55 years at diagnosis, clinical follow-up &gt;=5 years and at least one tomography scan &gt;=3 years after finished treatment. One hundred and three subjects were reviewed: 73 patients met all inclusion criteria, while 30 patients fulfilled the inclusion criteria except for available tomography scan &gt;=3 years after therapy. The mean imaging follow-up was 11.2 +- 7.6 years and the mean clinical follow-up was 15.0 +- 6.9 years. In 20 (27%) subjects 27 cases grade I radiation-related toxicities were found; 9 (33%) of those 27 cases were clinically silent. In 14 (19%) females only grade I toxicities were observed. Grade III-IV toxicities were found in 5 (6.8%) subjects. No grade V toxicities were observed. We concluded that severe late side effects caused by radiotherapy were exceedingly rare in females successfully treated for early-stage cervical carcinoma, only 1 bilateral osteonecrosis, 2 cases of ileus, and 2 potentially radiation-induced tumors were found. The majority of radiation-related comorbidities found on imaging scans were clinically silent.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathology &amp; Oncology Research

ISSN

1219-4956

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

September

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

1609915

UT code for WoS article

000706310800001

EID of the result in the Scopus database

2-s2.0-85117085621