Corpus callosum hypersignals and focal atrophy: neuroimaging findings in globular glial tauopathy type I

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43922029" target="_blank" >RIV/00216208:11120/22:43922029 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/21:N0000025 RIV/00023884:_____/21:00008959 RIV/00064190:_____/22:N0000129
Result on the web
<a href="https://doi.org/10.1111/ene.15090" target="_blank" >https://doi.org/10.1111/ene.15090</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ene.15090" target="_blank" >10.1111/ene.15090</a>

Result language
angličtina
Original language name
Corpus callosum hypersignals and focal atrophy: neuroimaging findings in globular glial tauopathy type I
Original language description
BACKGROUND: Globular glial tauopathies (GGT) have heterogeneous presentations, little evidence regarding typical clinical and MRI presentations are available. METHODS: We retrospectively assessed MRIs from three postmortem confirmed GGT cases, in two patients with atypical progressive aphasia and one with corticobasal syndrome. RESULTS: We suggest four principal concomitant MRI findings to characterize GGT type I: a sagittal callosal hyperintense band, marked focal callosal atrophy suggesting white matter degeneration originating in cortical areas responsible for symptoms (anterior atrophy in predominantly language manifestations and posterior atrophy in predominantly apraxia), periventricular white matter lesions, and mild-to-moderate brainstem atrophy. CONCLUSIONS: We observed four concomitant MRI abnormalities in patients with atypical dementia, parkinsonism, and late incomplete supranuclear gaze palsy. Two patients had atypical progressive aphasia and one had corticobasal syndrome.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology

Project
<a href="/en/project/NV19-04-00090" target="_blank" >NV19-04-00090: Overlap of neurodegenerative dementias and their clinic-pathological correlations: a prospective-retrospective multicentric study</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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