The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43922780" target="_blank" >RIV/00216208:11120/22:43922780 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/ijms23020761" target="_blank" >https://doi.org/10.3390/ijms23020761</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms23020761" target="_blank" >10.3390/ijms23020761</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions
Original language description
Drug addiction causes constant serious health, social, and economic burden within the human society. The current drug dependence pharmacotherapies, particularly relapse prevention, remain limited, unsatisfactory, unreliable for opioids and tobacco, and even symptomatic for stimulants and cannabinoids, thus, new more effective treatment strategies are researched. The antagonism of the growth hormone secretagogue receptor type A (GHS-R1A) has been recently proposed as a novel alcohol addiction treatment strategy, and it has been intensively studied in experimental models of other addictive drugs, such as nicotine, stimulants, opioids and cannabinoids. The role of ghrelin signaling in these drugs effects has also been investigated. The present review aims to provide a comprehensive overview of preclinical and clinical studies focused on ghrelin's/GHS-R1A possible involvement in these nonalcohol addictive drugs reinforcing effects and addiction. Although the investigation is still in its early stage, majority of the existing reviewed experimental results from rodents with the addition of few human studies, that searched correlations between the genetic variations of the ghrelin signaling or the ghrelin blood content with the addictive drugs effects, have indicated the importance of the ghrelin's/GHS-R1As involvement in the nonalcohol abused drugs pro-addictive effects. Further research is necessary to elucidate the exact involved mechanisms and to verify the future potential utilization and safety of the GHS-R1A antagonism use for these drug addiction therapies, particularly for reducing the risk of relapse.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30312 - Substance abuse
Result continuities
Project
<a href="/en/project/GA21-30795S" target="_blank" >GA21-30795S: Modulations of mesolimbic ghrelin signalling – a new hope for methamphetamine addiction treatment?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
23
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
31
Pages from-to
761
UT code for WoS article
000746183500001
EID of the result in the Scopus database
2-s2.0-85122525708