The omega of TRPM7 channels in trigeminal neuralgia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43924030" target="_blank" >RIV/00216208:11120/22:43924030 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s00424-022-02757-w" target="_blank" >https://doi.org/10.1007/s00424-022-02757-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00424-022-02757-w" target="_blank" >10.1007/s00424-022-02757-w</a>
Alternative languages
Result language
angličtina
Original language name
The omega of TRPM7 channels in trigeminal neuralgia
Original language description
Trigeminal neuralgia (TN), traditionally referred as tic douloureux, is a rare (incidence of about 4 per 100,000 cases per year) form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face [4]. While the etiology of TN is not fully understood, most cases occur in a sporadic manner and are associated with intracranial vascular compression of the trigeminal nerve root that is often assumed to be the pain-initiating mechanism. However, although compression of the trigeminal root appears to be common in the aging population, only few individuals develop TN [7]. Conversely, many TN patients do no show compression of the trigeminal nerve [8]. TN can also occur in a familial manner suggesting the existence of predisposing genetic factors [3]. Whole genome sequencing studies have indeed revealed numerous genetic variants especially in genes encoding ion channels [9]. However, the pathological relevance of ion channel variants in the etiology of TN remains largely unknown.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů