Serotonergic modulation of local network processing in V1 mirrors previously reported signatures of local network modulation by spatial attention

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43925225" target="_blank" >RIV/00216208:11120/23:43925225 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1111/ejn.15953" target="_blank" >https://doi.org/10.1111/ejn.15953</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ejn.15953" target="_blank" >10.1111/ejn.15953</a>

Result language

angličtina

Original language name

Serotonergic modulation of local network processing in V1 mirrors previously reported signatures of local network modulation by spatial attention

Original language description

Sensory processing is influenced by neuromodulators such as serotonin, thought to relay behavioral state. Recent work has shown that the modulatory effect of serotonin itself differs with the animal&apos;s behavioral state. In primates, including humans (Beliveau et al., 2017), the serotonin system is anatomically important in the primary visual cortex (V1) (Jacob and Nienborg, 2018). We previously reported that in awake fixating macaques, serotonin reduces the spiking activity by decreasing response gain in V1 (Seillier et al., 2017). But the effect of serotonin on the local network is unknown. Here, we simultaneously recorded single-unit activity and local field potentials (LFP) while iontophoretically applying serotonin in V1 of alert monkeys fixating on a video screen for juice rewards. The reduction in spiking response we observed previously is the opposite of the known increase of spiking activity with of spatial attention. Conversely, in the local network (LFP) the application of serotonin resulted in changes mirroring the local network effects of previous reports in macaques directing spatial attention to the receptive field (Chalk et al., 2010). It reduced the LFP power and the spike-field coherence, and the LFP became less predictive of spiking activity, consistent with reduced functional connectivity. We speculate that together, these effects may reflect the sensory side of a serotonergic contribution to quiet vigilance: the lower gain reduces the salience of stimuli to suppress an orienting reflex to novel stimuli while at the network level, visual processing is in a state comparable to that of spatial attention.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Neuroscience

ISSN

0953-816X

e-ISSN

1460-9568

Volume of the periodical

57

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

1368-1382

UT code for WoS article

000957847600001

EID of the result in the Scopus database

2-s2.0-85151425638