Methylphenidate Attenuates Signs of Evoked Neuropathic Pain in Animal Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43926180" target="_blank" >RIV/00216208:11120/23:43926180 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.33549/physiolres.935215" target="_blank" >https://doi.org/10.33549/physiolres.935215</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935215" target="_blank" >10.33549/physiolres.935215</a>
Alternative languages
Result language
angličtina
Original language name
Methylphenidate Attenuates Signs of Evoked Neuropathic Pain in Animal Model
Original language description
Methylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We evaluated the effect of methylphenidate (1 mg/kg, s.c.) on evoked pain (reflex tests - plantar test, vonFrey test and operant test - thermal place preference) and on spontaneous pain (conditioned place preference). CCI induced thermal, mechanical and cold hyperalgesia/allodynia. Methyphenidate suppressed mechanical and cold hyperalgesia/allodynia, while had no effect on thermal one. Therefore, methylphenidate seems to be a new potential pharmacotherapy for the treatment of neuropathic pain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
72
Issue of the periodical within the volume
Suppl. 5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
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UT code for WoS article
001198072000011
EID of the result in the Scopus database
2-s2.0-85181544114