Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F24%3A43926608" target="_blank" >RIV/00216208:11120/24:43926608 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1186/s42826-024-00192-9" target="_blank" >https://doi.org/10.1186/s42826-024-00192-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s42826-024-00192-9" target="_blank" >10.1186/s42826-024-00192-9</a>
Alternative languages
Result language
angličtina
Original language name
Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence
Original language description
Background Methamphetamine (MA) is a highly abused psychostimulant across all age groups including pregnant women. Because developing brain is vulnerable by the action of drugs, or other noxious stimuli, the aim of our study was to examine the effect of early postnatal administration of MA alone or in combination with enriched environment (EE) and/or stress of separate housing, on the levels of serotonin (5HT) in the hippocampus of male rat pups at three stages of adolescence (postnatal day (PND) 28, 35 and 45). MA (5 mg/kg/ml) was administered subcutaneously (sc) to pups (direct administration), or via mothers' milk between PND1 and PND12 (indirect administration). Controls were exposed saline (SA). Pups were exposed to EE and/or to separation from the weaning till the end of the experiment. Results On PND 28, in sc-treated series, EE significantly increased the muted 5HT in SA pups after separation and restored the pronounced inhibition of 5HT by MA. No beneficial effect of EE was present in pups exposed to combination of MA and separation. 5HT development declined over time; EE, MA and separation had different effects on 5HT relative to adolescence stage. Conclusions Present study shows that MA along with environment or housing affect 5HT levels, depending on both the age and the method of application (direct or indirect). These findings extend the knowledge on the effects of MA alone and in combination with different housing conditions on the developing brain and highlight the increased sensitivity to MA during the first few months after birth.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Laboratory Animal Research
ISSN
1738-6055
e-ISSN
2233-7660
Volume of the periodical
40
Issue of the periodical within the volume
February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1
UT code for WoS article
001155414600001
EID of the result in the Scopus database
2-s2.0-85183692034