Chelating mitochondrial iron and copper: Recipes, pitfalls and promise
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F24%3A43927060" target="_blank" >RIV/00216208:11120/24:43927060 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.mito.2024.101903" target="_blank" >https://doi.org/10.1016/j.mito.2024.101903</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mito.2024.101903" target="_blank" >10.1016/j.mito.2024.101903</a>
Alternative languages
Result language
angličtina
Original language name
Chelating mitochondrial iron and copper: Recipes, pitfalls and promise
Original language description
Iron and copper chelation therapy plays a crucial role in treating conditions associated with metal overload, such as hemochromatosis or Wilson's disease. However, conventional chelators face challenges in reaching the core of iron and copper metabolism - the mitochondria. Mitochondria-targeted chelators can specifically target and remove metal ions from mitochondria, showing promise in treating diseases linked to mitochondrial dysfunction, including neurodegenerative diseases and cancer. Additionally, they serve as specific mitochondrial metal sensors. However, designing these new molecules presents its own set of challenges. Depending on the chelator's intended use to prevent or to promote redox cycling of the metals, the chelating moiety must possess different donor atoms and an optimal value of the electrode potential of the chelator-metal complex. Various targeting moieties can be employed for selective delivery into the mitochondria. This review also provides an overview of the current progress in the design of mitochondria-targeted chelators and their biological activity investigation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mitochondrion
ISSN
1567-7249
e-ISSN
1872-8278
Volume of the periodical
78
Issue of the periodical within the volume
September
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
101903
UT code for WoS article
001247972200001
EID of the result in the Scopus database
2-s2.0-85194348778