Number of children and risk of dementia: a cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F25%3A43927749" target="_blank" >RIV/00216208:11120/25:43927749 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10487778
Result on the web
<a href="https://doi.org/10.1136/jech-2024-222717" target="_blank" >https://doi.org/10.1136/jech-2024-222717</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jech-2024-222717" target="_blank" >10.1136/jech-2024-222717</a>
Alternative languages
Result language
angličtina
Original language name
Number of children and risk of dementia: a cohort study
Original language description
BACKGROUND: Findings on the link between the number of children and dementia risk are inconsistent, mostly studied in females, suggesting pregnancy-related changes may be a key factor in this association. METHODS: The Adult Changes in Thought Study is a cohort of adults aged >=65 years from Kaiser Permanente Washington. The primary exposure was the number of children (0, 1, 2, 3 or >=4), and the outcome was an incident dementia diagnosis. Cox proportional-hazards models were adjusted for demographic and early-life socioeconomic confounders. Models were then stratified by sex and by birth year <1928 versus >=1928. RESULTS: Among 4668 participants (average age at enrolment 74.1+-SD 6.3 years; 59% female), 967 (21%) had 0 children, 484 (10%) had one child, 1240 (27%) had two children, 968 (21%) had three children and 1009 (22%) had four or more children. We found no association between the number of children and dementia overall or after stratification by birth cohort. When stratified by sex and adjusting for confounders, having >=4 children compared with two children was associated with a higher rate of dementia in males (HR=1.31, 95% CI 1.01 to 1.71). CONCLUSIONS: The number of children was not consistently associated with the risk of dementia. We observed a greater risk of dementia only among males who had >=4 children, with the lower bound of the 95% CI marginally exceeding 1. These findings suggest that the number of children may influence the risk of dementia through other than pregnancy-related pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Epidemiology and Community Health
ISSN
0143-005X
e-ISSN
1470-2738
Volume of the periodical
79
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
280-287
UT code for WoS article
001361819800001
EID of the result in the Scopus database
2-s2.0-85214488158