Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F25%3A43928298" target="_blank" >RIV/00216208:11120/25:43928298 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/ph18030364" target="_blank" >https://doi.org/10.3390/ph18030364</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ph18030364" target="_blank" >10.3390/ph18030364</a>
Alternative languages
Result language
angličtina
Original language name
Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways
Original language description
The rising burden of fungal infections presents a significant challenge to global healthcare, particularly with increasing antifungal resistance limiting treatment efficacy. Early detection and timely intervention remain critical, yet fungal pathogens employ diverse mechanisms to evade host immunity and develop resistance, undermining existing therapeutic options. Limited antifungal options and rising resistance necessitate novel treatment strategies. This review provides a comprehensive overview of conventional antifungal agents, their mechanisms of action, and emerging resistance pathways. Furthermore, it highlights recently approved and investigational antifungal compounds while evaluating innovative approaches such as nanotechnology, drug repurposing, and immunotherapy. Addressing antifungal resistance requires a multifaceted strategy that integrates novel therapeutics, enhanced diagnostic tools, and future research efforts to develop sustainable and effective treatment solutions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceuticals
ISSN
1424-8247
e-ISSN
1424-8247
Volume of the periodical
18
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
33
Pages from-to
364
UT code for WoS article
001452121700001
EID of the result in the Scopus database
2-s2.0-105000957086