KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F25%3A43928331" target="_blank" >RIV/00216208:11120/25:43928331 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1038/s41413-025-00415-2" target="_blank" >https://doi.org/10.1038/s41413-025-00415-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41413-025-00415-2" target="_blank" >10.1038/s41413-025-00415-2</a>

Result language

angličtina

Original language name

KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism

Original language description

An increasing number of studies have characterized the bone as an endocrine organ, and that bone secreted factors may not only regulate local bone remodeling, but also other tissues and whole-body metabolic functions. The precise nature of these regulatory factors and their roles at bridging the bone, bone marrow adipose tissue, extramedullary body fat and whole-body energy homeostasis are being explored. In this study, we report that KIAA1199, a secreted factor produced from bone and bone marrow, previously described as an inhibitor of bone formation, also plays a role at promoting adipogenesis. KIAA1199-deficient mice exhibit reduced bone marrow adipose tissue, subcutaneous and visceral fat tissue mass, blood cholesterol, triglycerides, free fatty acids and glycerol, as well as improved insulin sensitivity in skeletal muscle, liver and fat. Moreover, these mice are protected from the detrimental effects of high-fat diet feeding, with decreased obesity, lower blood glucose and glucose tolerance, as well as decreased adipose tissue inflammation, insulin resistance and hepatic steatosis. In human studies, plasma levels of KIAA1199 or its expression levels in adipose tissue are positively correlated with insulin resistance and blood levels of cholesterol, triglycerides, free fatty acids, glycerol, fasting glucose and HOMA-IR. Mechanistically, KIAA1199 mediates its effects on adipogenesis through modulating osteopontin-integrin and AKT / ERK signaling. These findings provide evidence for the role of bone secreted factors on coupling bone, fat and whole-body energy homeostasis.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bone Research

ISSN

2095-4700

e-ISSN

2095-6231

Volume of the periodical

13

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

43

UT code for WoS article

001457384100001

EID of the result in the Scopus database

2-s2.0-105001515633