Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F98%3A43896440" target="_blank" >RIV/00216208:11120/98:43896440 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S0006-8993(98)00367-9" target="_blank" >http://dx.doi.org/10.1016/S0006-8993(98)00367-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0006-8993(98)00367-9" target="_blank" >10.1016/S0006-8993(98)00367-9</a>
Alternative languages
Result language
angličtina
Original language name
Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility
Original language description
The present study examined the ovarian hormonal regulation of seizure susceptibility in prenatally morphine- and saline-exposed adult female rats in the flurothyl seizure model in vivo, and in low-magnesium-induced epileptiform activity in brain slices, in vitro. All females were ovariohysterectomized (OVX); some received either estrogen (E) or progesterone (P) replacement, while others were injected with E + P sequentially. In prenatally saline-treated control females, there was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the presence of both hormones (E + P) compared to OVX controls. In morphine-exposed females, there was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone while there was a reduced tonic-clonic seizure threshold in the presence of both hormones (E + P) compared to the hormone treatment-matched group of saline-exposed females, In control females, in low magnesium medium in vitro, the development of two types of epileptiform activity (seizure-like events and status of short discharges) was not affected by the different hormonal conditions. However, prenatal morphine exposure suppressed the development of both types of epileptiform activity in the E-injected females compared to the E-injected, control females. The present data demonstrate that the anticonvulsant effects of P on seizure susceptibility requires the presence of E, Furthermore, prenatal morphine exposure alters ovarian steroid hormone-regulated seizure susceptibility
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IZ3613" target="_blank" >IZ3613: Effects of repeated seizures and long-term antiepileptic therapy on brain morphology and function</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
1998
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Research
ISSN
0006-8993
e-ISSN
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Volume of the periodical
796
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
247-256
UT code for WoS article
000074784000028
EID of the result in the Scopus database
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