Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of N-G-nitro-L-arginine-methyl ester hypertensive rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F09%3A5310" target="_blank" >RIV/00216208:11130/09:5310 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/09:00330732

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of N-G-nitro-L-arginine-methyl ester hypertensive rats

Original language description

Objective Melatonin was shown to reduce blood pressure, enhance nitric oxide availability and scavenge free radicals. There is, however, a shortage of data with respect to the effect of melatonin on pathological left ventricular remodelling associated with haemodynamic overload. Design We investigated whether melatonin was able to prevent left ventricular hypertrophy (LVH) and fibrosis associated with N-G-nitro-L-arginine-methyl ester (L-NAME)induced hypertension. Methods Four groups of male Wistar ratswere investigated: control, L-NAME (50 mg/kg per day), melatonin (10 mg/kg per day) and L-NAME plus melatonin. Blood pressure was measured non-invasively each week. After 5 weeks of treatment the animals were killed and nitric oxide synthase (NOS) activity, endothelial and inducible NOS expression, the level of collagenous proteins, hydroxyproline and conjugated dienes in the left ventricle were determined. Results The administration of L-NAME inhibited NOS activity, increased conjugate

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/GA305%2F08%2F0139" target="_blank" >GA305/08/0139: Altered regulation of vasoactive system balance in experimental hypertension</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Hypertension

ISSN

0263-6352

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

Suppl. 6

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000269549400003

EID of the result in the Scopus database

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