Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate Quinone Oxidoreductase Polymorphisms and Pancreatic Cancer Risk
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A6939" target="_blank" >RIV/00216208:11130/11:6939 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/11:0024 RIV/75010330:_____/11:00009217 RIV/00216208:11110/11:9330
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/20966810" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/20966810</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate Quinone Oxidoreductase Polymorphisms and Pancreatic Cancer Risk
Original language description
Objectives: Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684)with pancreatic cancer risk was studied. Methods: Polymorphisms were studied by allelic discrimination. Results: In a hospital-based case-control study on 500 individuals (235 cases and 265 controls) of Czech white origin, SOD2, SOD3, NQO1, and NQO2 polymorphisms showed no significant association with pancreatic cancer risk. Major lifestyle factors such as smoking and alcohol, coffee, or tea consumption did not modify the effect of the studied polymorphisms. Conclusions: The first Europ
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9422" target="_blank" >NR9422: Influence (role) of environment and genetic determinants (profile) of pancreatic cancer.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pancreas
ISSN
0885-3177
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
72-78
UT code for WoS article
000285375900015
EID of the result in the Scopus database
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