The Course of Heart Failure Development and Mortality in Rats with Volume Overload due to Aorto-Caval Fistula

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8076" target="_blank" >RIV/00216208:11130/12:8076 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/12:00056133

Result on the web

<a href="http://dx.doi.org/10.1159/000331562" target="_blank" >http://dx.doi.org/10.1159/000331562</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Course of Heart Failure Development and Mortality in Rats with Volume Overload due to Aorto-Caval Fistula

Original language description

Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examinethe relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurredearlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = -0.51, p < 0.001). Conclusion: The median s

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney & Blood Pressure Research

ISSN

1420-4096

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

167-173

UT code for WoS article

000303273500005

EID of the result in the Scopus database

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