Cardiac Tolerance to Ischemia in Neonatal Spontaneously Hypertensive Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8217" target="_blank" >RIV/00216208:11130/12:8217 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/12:00380491

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S145.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S145.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cardiac Tolerance to Ischemia in Neonatal Spontaneously Hypertensive Rats

Original language description

Hypertension is the risk factor of serious cardiovascular diseases, such as ischemic heart disease and atherosclerosis. The aim of the present study was to analyze the development of cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats (SHR) and possible protective effect of ischemic preconditioning (IP) or adaptation to intermittent high-altitude hypoxia (IHAH). For this purpose we used 1- and 10-day-old pups of SHR and their normotensive control Wistar Kyoto rats (WKY). Isolated hearts were perfused in the Langendorff mode with Krebs-Henseleit solution at constant pressure, temperature and rate. Cardiac tolerance to ischemia was expressed as a percentage of baseline values of developed force (DF) after global ischemia. IP was induced by three 3-min periods of global ischemia, each separated by 5-min periods of reperfusion. IHAH was simulated in barochamber (8 h/day, 5000 m) from postnatal day 1 to 10. Cardiac tolerance to ischemia in 1-day-old SHR was higher than

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/1M0510" target="_blank" >1M0510: Centre for cardiovascular research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

"S145"-"S153"

UT code for WoS article

000307133700011

EID of the result in the Scopus database

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