Endogenous ligands of benzodiazepine binding site have inverse agonistic properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10196639" target="_blank" >RIV/00216208:11130/13:10196639 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058765 RIV/00216208:11120/13:43907654

Result on the web

<a href="http://dx.doi.org/10.1016/j.mehy.2013.10.006" target="_blank" >http://dx.doi.org/10.1016/j.mehy.2013.10.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mehy.2013.10.006" target="_blank" >10.1016/j.mehy.2013.10.006</a>

Result language

angličtina

Original language name

Endogenous ligands of benzodiazepine binding site have inverse agonistic properties

Original language description

Benzodiazepines have been widely used in clinical praxis for many decades. They act as GABA(A) receptor agonists and possess muscle-relaxant, hypnotic-sedative, anticonvulsant, and anxiolytic properties. Flumazenil acts as a benzodiazepine receptor antagonist (subunits alpha(1), alpha(2), alpha(3), and alpha(5)) or partial agonist (subunits alpha(4) and alpha(6)). It competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversingthe effects of benzodiazepines. In our experiments, administration of flumazenil in rabbits was surprisingly associated with anxiolytic effects similar to those of midazolam. Additionally, flumazenil significantly and dose-dependently decreased the totalnumber of vocalizations in rats, i.e. it was anxiolytic. These observations seem to be in contrast to the effect of flumazenil in humans, where it is believed to produce mainly anxiogenic effects. It seems that in individuals, who exhibi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Hypotheses

ISSN

0306-9877

e-ISSN

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Volume of the periodical

81

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

1075-1077

UT code for WoS article

000329334800025

EID of the result in the Scopus database

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