Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209793" target="_blank" >RIV/00216208:11130/13:10209793 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.resp.2012.11.012" target="_blank" >http://dx.doi.org/10.1016/j.resp.2012.11.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.resp.2012.11.012" target="_blank" >10.1016/j.resp.2012.11.012</a>
Alternative languages
Result language
angličtina
Original language name
Chronic hypoxia inhibits tetrahydrobiopterin-induced NO production in rat lungs
Original language description
Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthases (NOS). Oxidative stress oxidises BH4 to dihydrobioptein (BH2), resulting in the uncoupling of the two enzymatic domains of NOS and the production of superoxide rather than NO (NOS uncoupling). Oxidative stress is known to be increased in the early stage of chronic hypoxia. This study investigated the participation of NOS uncoupling in the early phase of hypoxia-induced pulmonary hypertension in rats. Rats were exposed to 10% O-2 for 4 days. We investigated the effect of BH4 in vitro on isolated rat lungs and isolated rat peripheral pulmonary blood vessels and in vivo on exhaled NO concentration in exhaled air. BH4 attenuated hypoxic pulmonary vasoconstriction in isolated lungs and its effect was reversed by L-NAME (NOS inhibitor). The main finding of the study is that the effect of BH4 was smaller in rats exposed to 4 days of hypoxia than in normoxic controls. The finding was similar in isolated pulmonary blo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Respiratory Physiology and Neurobiology
ISSN
1569-9048
e-ISSN
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Volume of the periodical
185
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
547-552
UT code for WoS article
000315322900009
EID of the result in the Scopus database
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