Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293064" target="_blank" >RIV/00216208:11130/14:10293064 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00435640
Result on the web
<a href="http://dx.doi.org/10.1186/s13028-014-0072-0" target="_blank" >http://dx.doi.org/10.1186/s13028-014-0072-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13028-014-0072-0" target="_blank" >10.1186/s13028-014-0072-0</a>

Result language
angličtina
Original language name
Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia
Original language description
Background: Hypoxia results in an imbalance between oxygen supply and oxygen consumption. This study utilized microdialysis to monitor changes in the energy-related metabolites lactate, pyruvate and glucose in rat muscle before, during and after 30 minutes of transient global hypoxia. Hypoxia was induced in anaesthetised rats by reducing inspired oxygen to 6% O-2 in nitrogen. Results: Basal values for lactate, the lactate/pyruvate ratio and glucose were 0.72 +/- 0.04 mmol/l, 10.03 +/- 1.16 and 3.55 +/-0.19 mmol/l (n = 10), respectively. Significant increases in lactate and the lactate/pyruvate ratio were found in the muscle after the induction of hypoxia. Maximum values of 2.26 +/- 0.37 mmol/l for lactate were reached during early reperfusion, while the lactate/pyruvate ratio reached maximum values of 35.84 +/- 7.81 at the end of hypoxia. Following recovery to ventilation with air, extracellular lactate levels and the lactate/pyruvate ratio returned to control levels within 30-40 minu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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