Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294521" target="_blank" >RIV/00216208:11130/15:10294521 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10294521
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2014.107706" target="_blank" >http://dx.doi.org/10.3324/haematol.2014.107706</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2014.107706" target="_blank" >10.3324/haematol.2014.107706</a>
Alternative languages
Result language
angličtina
Original language name
Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood
Original language description
Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia fromthe immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone marrow has been shown to be a valuable diagnostic tool in differentiating myelodysplastic syndrome from non-clonal cytopenias in adults. Here, we performed the first comprehensive flow cytometric analysis of immature myeloid, lymphoid cells and erythroid cells, and granulocytes, monocytes, and lymphoid cells in bone marrow obtained from a large prospective cohort of 81 children with refractory cytopenia. Children with refractory cyotopenia had a strongly reduced myeloid compartment, but not as severe as children with aplastic anemia. Furthermore, the number of flow cytometric abnormalities was sign
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14534" target="_blank" >NT14534: Role of flow cytometry and advanced molecular techniques in diagnosis of bone marrow failure syndromes in childhood</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
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Volume of the periodical
100
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
9
Pages from-to
315-323
UT code for WoS article
000351279900020
EID of the result in the Scopus database
2-s2.0-84924709594