Trial watch: Naked and vectored DNA-based anticancer vaccines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294959" target="_blank" >RIV/00216208:11130/15:10294959 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10294959
Result on the web
<a href="http://dx.doi.org/10.1080/2162402X.2015.1026531" target="_blank" >http://dx.doi.org/10.1080/2162402X.2015.1026531</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/2162402X.2015.1026531" target="_blank" >10.1080/2162402X.2015.1026531</a>
Alternative languages
Result language
angličtina
Original language name
Trial watch: Naked and vectored DNA-based anticancer vaccines
Original language description
One type of anticancer vaccine relies on the administration of DNA constructs encoding one or multiple tumor-associated antigens (TAAs). The ultimate objective of these preparations, which can be naked or vectored by non-pathogenic viruses, bacteria or yeast cells, is to drive the synthesis of TAAs in the context of an immunostimulatory milieu, resulting in the (re-)elicitation of a tumor-targeting immune response. In spite of encouraging preclinical results, the clinical efficacy of DNA-based vaccinesemployed as standalone immunotherapeutic interventions in cancer patients appears to be limited. Thus, efforts are currently being devoted to the development of combinatorial regimens that allow DNA-based anticancer vaccines to elicit clinically relevantimmune responses. Here, we discuss recent advances in the preclinical and clinical development of this therapeutic paradigm.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
OncoImmunology [online]
ISSN
2162-402X
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
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UT code for WoS article
000354985400022
EID of the result in the Scopus database
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