White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295045" target="_blank" >RIV/00216208:11130/15:10295045 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/15:00062868 RIV/00064203:_____/15:10295045
Result on the web
<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007" target="_blank" >http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007" target="_blank" >10.1016/j.neurobiolaging.2015.03.007</a>

Result language
angličtina
Original language name
White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging
Original language description
Many patients with dementia with Lewy bodies (DLB) have overlapping Alzheimer's disease (AD) erelated pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n = 30),age-and sex-matched AD patients (n = 30), and cognitively normal controls (n = 60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-D-glucose, and C-11 Pittsburgh compound B positron emission tomography scans. DLB patients had reduced fractional anisotropy (FA) in the parietooccipital WM but not elsewhere compared with cognitively normal controls, and elevated FA in parahippocampal WM compared with AD patients, which persisted after controlling for b-amyloid load in DLB. The pattern of WMFA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of 2-fluoro-deoxy-D-glucose positron emission tomography in the cortex. DLB is characterized by a loss of parietooccipital
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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