Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295233" target="_blank" >RIV/00216208:11130/15:10295233 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10295233

Result on the web

<a href="http://dx.doi.org/10.1099/vir.0.068536-0" target="_blank" >http://dx.doi.org/10.1099/vir.0.068536-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/vir.0.068536-0" target="_blank" >10.1099/vir.0.068536-0</a>

Result language

angličtina

Original language name

Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators

Original language description

Human herpesvirus-6A (HHV-6A) is rarer than HHV-6B in many infant populations. However, they are similarly prevalent as germline, chromosomally integrated genomes (ciHHV-6A/B). This integrated form affects 0.1-1% of the human population, where potentially virus gene expression could be in every cell, although virus relationships and health effects are not clear. In a Czech/German patient cohort ciHHV-6A was more common and diverse than ciHHV-6B. Quantitative PCR, nucleotide sequencing and telomeric integration site amplification characterized ciHHV-6 in 44 German myocarditis/cardiomyopathy and Czech malignancy/inflammatory disease (MI) patients plus donors. Comparisons were made to sequences from global virus reference strains, and blood DNA from childhood-infections from Zambia (HHV-6A mainly) and Japan (HHV-6B). The MI cohort were 86% (18/21) ciHHV-6A, the cardiac cohort 65% (13/20) ciHHV-6B, suggesting different disease links. Reactivation was supported by findings of 1) recombinati

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of General Virology

ISSN

0022-1317

e-ISSN

—

Volume of the periodical

96

Issue of the periodical within the volume

Part 2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

20

Pages from-to

370-389

UT code for WoS article

000355784700015

EID of the result in the Scopus database

2-s2.0-84921791181