The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295234" target="_blank" >RIV/00216208:11130/15:10295234 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10295234
Result on the web
<a href="http://dx.doi.org/10.4274/jcrpe.1891" target="_blank" >http://dx.doi.org/10.4274/jcrpe.1891</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4274/jcrpe.1891" target="_blank" >10.4274/jcrpe.1891</a>
Alternative languages
Result language
angličtina
Original language name
The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia
Original language description
Insulin secretion from pancreatic beta-cells is tightly regulated to keep fasting blood glucose concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia (HH) is a heterozygous condition in which insulin secretion becomes unregulated and its production persists despite low blood glucose levels. It is the most common cause of severe and persistent hypoglycaemia in neonates and children. The most severe and permanent forms are due to congenital hyperinsulinism (CHI). Recentadvances in genetics have linked CHI to mutations in 9 genes that play a key role in regulating insulin secretion (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A and HNF1A). Histologically, CHI can be divided into 3 types; diffuse, focal and atypical. Given the biochemical nature of HH (non-ketotic), a delay in the diagnosis and management can result in irreversible brain damage. Therefore, it is essential to diagnose and treat HH promptly. Advances in molecular genetics, imaging
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JCRPE Journal of Clinical Research in Pediatric Endocrinology
ISSN
1308-5727
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
2
Country of publishing house
TR - TURKEY
Number of pages
12
Pages from-to
86-97
UT code for WoS article
000355936400001
EID of the result in the Scopus database
2-s2.0-84930439901