The Relationships Between Quantitative MR Parameters in Hippocampus in Healthy Subjects and Patients With Temporal Lobe Epilepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295702" target="_blank" >RIV/00216208:11130/15:10295702 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10295702 RIV/00023001:_____/15:00059092

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_407.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_407.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Relationships Between Quantitative MR Parameters in Hippocampus in Healthy Subjects and Patients With Temporal Lobe Epilepsy

Original language description

We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogeniczone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. The measurement protocol contained T2-weighted MR images, spectroscopic imaging, diffusion tensor imaging and T2relaxometry. Correlations between quantitative MR parameters were calculated on a pixel-by-pixel basis using the CORIMA program which enables automated pixel identification in the normal tissue according to control data. All MR parameters changed in theanteroposterior direction in the hippocampus and correlation patterns and their slopes differed between patients and controls. Combinations of T2 relaxation times with metabolite values represent the best biomarkers of the epileptogenic

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/NS9915" target="_blank" >NS9915: Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

407-417

UT code for WoS article

000357411100013

EID of the result in the Scopus database

2-s2.0-84934276699