Changes in the Composition of Fatty Acids and Lipofuscin-Like Pigments During Development of Rat Heart

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315619" target="_blank" >RIV/00216208:11130/15:10315619 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/15:00454202

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_643.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_643.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Changes in the Composition of Fatty Acids and Lipofuscin-Like Pigments During Development of Rat Heart

Original language description

Postnatal heart development is characterized by critical periods of heart remodeling. In order to characterize the changes in the lipophilic fraction induced by free radicals, fatty acids and their oxidized products, lipofuscin-like pigments (LFP), wereinvestigated. Fatty acids were analyzed by gas chromatography and LFP were studied by fluorescence techniques. A fluorophore characterized by spectral methods was further resolved by HPLC. Major changes in the composition of fatty acids occurred immediately after birth and then during maturation. Fluorescence of LFP changed markedly on postnatal days 1, 4, 8, and 14, and differed from the adult animals. LFP comprise several fluorophores that were present since fetal state till adulthood. No new major fluorophores were formed during development, just the abundances of individual fluorophores have been modulated which produced changes in the shape of the spectral arrays. HPLC resolved the fluorophore with excitation maximum at 360 nm and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GAP303%2F11%2F0298" target="_blank" >GAP303/11/0298: Biochemical and morphological aspects of early postnatal development of rat heart and brain. The role of free radicals.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

643-651

UT code for WoS article

000367154800006

EID of the result in the Scopus database

2-s2.0-84953248051