Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315710" target="_blank" >RIV/00216208:11130/15:10315710 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10315710
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2015.124321" target="_blank" >http://dx.doi.org/10.3324/haematol.2015.124321</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2015.124321" target="_blank" >10.3324/haematol.2015.124321</a>
Alternative languages
Result language
angličtina
Original language name
Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia
Original language description
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of pediatric acute myeloid leukemia samples for deletions of the IKZF1 locus using multiplex ligation-dependent probe amplification and for mutations using direct sequencing. Three patients were identified with a single amino acid variant without change of IKZF1 length. No frame-shift mutations were found. Out of 11 patients with an IKZF1 deletion, 8 samples revealed a complete loss of chromosome 7, and 3 casesa focal deletion of 0.10.9Mb. These deletions included the complete IKZF1 gene (n=2) or exons 14 (n=1), all leading to a loss of IKZF1 function. Interestingly, differentially expressed genes in monosomy 7 cases (n=8) when compared to non
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
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Volume of the periodical
100
Issue of the periodical within the volume
9
Country of publishing house
IT - ITALY
Number of pages
9
Pages from-to
1151-1159
UT code for WoS article
000365081500025
EID of the result in the Scopus database
2-s2.0-84940949154