Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315973" target="_blank" >RIV/00216208:11130/15:10315973 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10315973
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2015.78" target="_blank" >http://dx.doi.org/10.1038/leu.2015.78</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2015.78" target="_blank" >10.1038/leu.2015.78</a>

Result language
angličtina
Original language name
Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia
Original language description
Philadelphia-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL) identifies an unfavorable subgroup of pediatric ALL characterized by the presence of the BCR-ABL1 chimeric protein. However, clinically Ph+ BCP-ALL remains a heterogeneousdisease with an unfavorable response to therapy in a critical percentage of patients. Even though introduction of tyrosine kinase inhibitors (TKIs) has improved outcome in pediatric PhMINUS SIGN BCP-ALL patients, 30% still relapse or die
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT13170" target="_blank" >NT13170: Biology and treatment of high-risk TEL/ABL-positive childhood acute lymphoblastic leukaemia</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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