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Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316015" target="_blank" >RIV/00216208:11130/15:10316015 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/15:10316015 RIV/00216224:14310/15:00087444

  • Result on the web

    <a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >http://dx.doi.org/10.1089/mdr.2014.0276</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >10.1089/mdr.2014.0276</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment

  • Original language description

    Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolatesfrom 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLSB) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLSB target site. The emergence ofMLSB resistance and mutations conferring resistance to MLSB antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneou

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12395" target="_blank" >NT12395: Molecular detection and analysis of invasive small colony variants of S. aureus and resistant S. aureus strains from patients with cystic fibrosis</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Microbial Drug Resistance

  • ISSN

    1076-6294

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    416-423

  • UT code for WoS article

    000363947200008

  • EID of the result in the Scopus database

    2-s2.0-84937784708