Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316015" target="_blank" >RIV/00216208:11130/15:10316015 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10316015 RIV/00216224:14310/15:00087444
Result on the web
<a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >http://dx.doi.org/10.1089/mdr.2014.0276</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >10.1089/mdr.2014.0276</a>
Alternative languages
Result language
angličtina
Original language name
Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment
Original language description
Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolatesfrom 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLSB) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLSB target site. The emergence ofMLSB resistance and mutations conferring resistance to MLSB antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneou
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12395" target="_blank" >NT12395: Molecular detection and analysis of invasive small colony variants of S. aureus and resistant S. aureus strains from patients with cystic fibrosis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbial Drug Resistance
ISSN
1076-6294
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
416-423
UT code for WoS article
000363947200008
EID of the result in the Scopus database
2-s2.0-84937784708