Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316020" target="_blank" >RIV/00216208:11130/15:10316020 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10316020
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >http://dx.doi.org/10.1038/leu.2015.59</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >10.1038/leu.2015.59</a>
Alternative languages
Result language
angličtina
Original language name
Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment
Original language description
The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hematopoietic stem cell transplantation (HSCT) aiming to evaluate the best time to assess minimal residual disease (MRD) for intervention strategies and in future trials in high-risk ALL relapse patients. Included patients (n = 125) were treated uniformly according to the ALL-REZ BFM (Berlin-Frankfurt-Munster) 2002 relapse trial (median follow-up time = 4.8 years). Patients with MRD }= 10(-3) after induction treatment (76/119, 64%) or immediately preceding HSCT (19/71, 27%) had a significantly worse probability of disease-free survival 10 years afterrelapse treatment begin, with 26% (+/- 6%) or 23% (+/- 7%), respectively, compared with 58% (+/- 8%) or 48% (+/- 7%) for patients with MRD < 10(-3). Conventional intensive consolidation treatment reduced MRD to < 10(-3) before HSCT in 63%
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molecular mechanisms of signaling through leukocyte receptors their role in health and disease.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1648-1655
UT code for WoS article
000360937200004
EID of the result in the Scopus database
2-s2.0-84938969742