All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316020" target="_blank" >RIV/00216208:11130/15:10316020 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/15:10316020

  • Result on the web

    <a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >http://dx.doi.org/10.1038/leu.2015.59</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >10.1038/leu.2015.59</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

  • Original language description

    The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hematopoietic stem cell transplantation (HSCT) aiming to evaluate the best time to assess minimal residual disease (MRD) for intervention strategies and in future trials in high-risk ALL relapse patients. Included patients (n = 125) were treated uniformly according to the ALL-REZ BFM (Berlin-Frankfurt-Munster) 2002 relapse trial (median follow-up time = 4.8 years). Patients with MRD }= 10(-3) after induction treatment (76/119, 64%) or immediately preceding HSCT (19/71, 27%) had a significantly worse probability of disease-free survival 10 years afterrelapse treatment begin, with 26% (+/- 6%) or 23% (+/- 7%), respectively, compared with 58% (+/- 8%) or 48% (+/- 7%) for patients with MRD < 10(-3). Conventional intensive consolidation treatment reduced MRD to < 10(-3) before HSCT in 63%

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molecular mechanisms of signaling through leukocyte receptors their role in health and disease.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia

  • ISSN

    0887-6924

  • e-ISSN

  • Volume of the periodical

    29

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    1648-1655

  • UT code for WoS article

    000360937200004

  • EID of the result in the Scopus database

    2-s2.0-84938969742