Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316020" target="_blank" >RIV/00216208:11130/15:10316020 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10316020
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >http://dx.doi.org/10.1038/leu.2015.59</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2015.59" target="_blank" >10.1038/leu.2015.59</a>

Result language
angličtina
Original language name
Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment
Original language description
The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hematopoietic stem cell transplantation (HSCT) aiming to evaluate the best time to assess minimal residual disease (MRD) for intervention strategies and in future trials in high-risk ALL relapse patients. Included patients (n = 125) were treated uniformly according to the ALL-REZ BFM (Berlin-Frankfurt-Munster) 2002 relapse trial (median follow-up time = 4.8 years). Patients with MRD }= 10(-3) after induction treatment (76/119, 64%) or immediately preceding HSCT (19/71, 27%) had a significantly worse probability of disease-free survival 10 years afterrelapse treatment begin, with 26% (+/- 6%) or 23% (+/- 7%), respectively, compared with 58% (+/- 8%) or 48% (+/- 7%) for patients with MRD < 10(-3). Conventional intensive consolidation treatment reduced MRD to < 10(-3) before HSCT in 63%
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molecular mechanisms of signaling through leukocyte receptors their role in health and disease.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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