LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316263" target="_blank" >RIV/00216208:11130/15:10316263 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10316263
Result on the web
<a href="http://dx.doi.org/10.1038/ng.3211" target="_blank" >http://dx.doi.org/10.1038/ng.3211</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ng.3211" target="_blank" >10.1038/ng.3211</a>
Alternative languages
Result language
angličtina
Original language name
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Original language description
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated distribution of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between inflation from a true polygenic signal and bias. We have developed an approach, LD Score regression, that quantifies the contribution of each by examining the relationship between test statistics and linkage disequilibrium (LD).The LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control. We find strong evidence that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Genetics
ISSN
1061-4036
e-ISSN
—
Volume of the periodical
47
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
291-295
UT code for WoS article
000350327900023
EID of the result in the Scopus database
2-s2.0-84923946495