Inhibitor development in non-severe haemophilia across Europe
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316271" target="_blank" >RIV/00216208:11130/15:10316271 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10316271
Result on the web
<a href="http://dx.doi.org/10.1160/TH14-12-1044" target="_blank" >http://dx.doi.org/10.1160/TH14-12-1044</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1160/TH14-12-1044" target="_blank" >10.1160/TH14-12-1044</a>
Alternative languages
Result language
angličtina
Original language name
Inhibitor development in non-severe haemophilia across Europe
Original language description
Evidence about inhibitor formation in non-severe haemophilia and the potential role for clotting factor concentrate type is scant. It was the aim of this study to report inhibitor development in non-severe haemophilia patients enrolled in the European Haemophilia Safety Surveillance (EUHASS) study. Inhibitors are reported quarterly and total treated patients annually. Incidence rates and 95% confidence intervals (95% Cl) were calculated according to diagnosis and concentrate used. Between 1-10-2008 and31-12-2012, 68 centres reported on 7,969 patients with non-severe haemophilia A and 1,863 patients with non-severe haemophilia B. For haemophilia A, 37 inhibitors occurred in 8,622 treatment years, resulting in an inhibitor rate of 0.43/100 treatment years (95% Cl 0.30-0.59). Inhibitors occurred at a median age of 35 years, after a median of 38 exposure days (EDs; P25-P75: 20-80); with 72% occurring within the first 50 EDs. In haemophilia B, one inhibitor was detected in 2,149 treatment
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Thrombosis and Haemostasis
ISSN
0340-6245
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
670-675
UT code for WoS article
000362144300003
EID of the result in the Scopus database
2-s2.0-84943166338