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Inhibitor development in non-severe haemophilia across Europe

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316271" target="_blank" >RIV/00216208:11130/15:10316271 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/15:10316271

  • Result on the web

    <a href="http://dx.doi.org/10.1160/TH14-12-1044" target="_blank" >http://dx.doi.org/10.1160/TH14-12-1044</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1160/TH14-12-1044" target="_blank" >10.1160/TH14-12-1044</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibitor development in non-severe haemophilia across Europe

  • Original language description

    Evidence about inhibitor formation in non-severe haemophilia and the potential role for clotting factor concentrate type is scant. It was the aim of this study to report inhibitor development in non-severe haemophilia patients enrolled in the European Haemophilia Safety Surveillance (EUHASS) study. Inhibitors are reported quarterly and total treated patients annually. Incidence rates and 95% confidence intervals (95% Cl) were calculated according to diagnosis and concentrate used. Between 1-10-2008 and31-12-2012, 68 centres reported on 7,969 patients with non-severe haemophilia A and 1,863 patients with non-severe haemophilia B. For haemophilia A, 37 inhibitors occurred in 8,622 treatment years, resulting in an inhibitor rate of 0.43/100 treatment years (95% Cl 0.30-0.59). Inhibitors occurred at a median age of 35 years, after a median of 38 exposure days (EDs; P25-P75: 20-80); with 72% occurring within the first 50 EDs. In haemophilia B, one inhibitor was detected in 2,149 treatment

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Thrombosis and Haemostasis

  • ISSN

    0340-6245

  • e-ISSN

  • Volume of the periodical

    114

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    6

  • Pages from-to

    670-675

  • UT code for WoS article

    000362144300003

  • EID of the result in the Scopus database

    2-s2.0-84943166338