Edoxaban for treatment of venous thromboembolism in patients with cancer Rationale and design of the Hokusai VTE-cancer study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10322984" target="_blank" >RIV/00216208:11130/15:10322984 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10322984

Result on the web

<a href="http://dx.doi.org/10.1160/TH15-06-0452" target="_blank" >http://dx.doi.org/10.1160/TH15-06-0452</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1160/TH15-06-0452" target="_blank" >10.1160/TH15-06-0452</a>

Result language

angličtina

Original language name

Edoxaban for treatment of venous thromboembolism in patients with cancer Rationale and design of the Hokusai VTE-cancer study

Original language description

Direct oral anticoagulants may be effective and safe for treatment of venous thromboembolism (VTE) in cancer patients, but they have not been compared with low-molecular-weight heparin (LMWH), the current recommended treatment for these patients. The Hokusai VTE-cancer study is a randomised, open-label, clinical trial to evaluate whether edoxaban, an oral factor Xa inhibitor, is non-inferior to LMWH for treatment of VTE in patients with cancer. We present the rationale and some design features of the study. One such feature is the composite primary outcome of recurrent VTE and major bleeding during a 12-month study period. These two complications occur frequently in cancer patients receiving anticoagulant treatment and have a significant impact. The evaluation beyond six months will fill the current gap in the evidence base for the long-term treatment of these patients. Based on the observation that the risk of recurrent VTE in patients with active cancer is similar to that in those wi

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis and Haemostasis

ISSN

0340-6245

e-ISSN

—

Volume of the periodical

114

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1268-1276

UT code for WoS article

000365769200020

EID of the result in the Scopus database

2-s2.0-84951336304