PNEI: life and death of skin cells. A new paradigm in the treatment of vitiligo: the low dose cytokines therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F16%3A10323797" target="_blank" >RIV/00216208:11130/16:10323797 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/dth.12268" target="_blank" >http://dx.doi.org/10.1111/dth.12268</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/dth.12268" target="_blank" >10.1111/dth.12268</a>
Alternative languages
Result language
angličtina
Original language name
PNEI: life and death of skin cells. A new paradigm in the treatment of vitiligo: the low dose cytokines therapy
Original language description
Barygina and coworkers evaluated the effects of low dose SKA IL-4, IL-10, b-fibroblast growth factor (b-FGF), and β-endorphin in the modulation of intracellular and extracellular oxidative stress and on the viability of human perilesional keratinocytes obtained from skin biopsies of vitiligo patients. Obtained results showed a significant reduction of intracellular oxidative stress with IL-4, IL-10, and b-FGF and the extracellular oxidative stress with IL-4 and b-FGF; increased cell viability with IL-10, b-FGF, and β-endorphin was also observed. In a retrospective spontaneous clinical study, Lotti and coworkers described the positive results in vitiligo treatment with low dose SKA cytokines alone or in association with microphototherapy with positive percentage of skin repigmentation in a number of patients varying between 74 and 90%.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FO - Dermatology and venereology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů