Chronic hypoxia increases fetoplacental vascular resistance in rat placenta perfused with blood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F16%3A10332612" target="_blank" >RIV/00216208:11130/16:10332612 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/BLL_2016_113" target="_blank" >http://dx.doi.org/10.4149/BLL_2016_113</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2016_113" target="_blank" >10.4149/BLL_2016_113</a>

Result language

angličtina

Original language name

Chronic hypoxia increases fetoplacental vascular resistance in rat placenta perfused with blood

Original language description

BACKGROUND: Chronic hypoxia elevates vascular resistance on the fetal side of the placenta. However, when a low-viscosity perfusate is used, the increase in resistance caused by chronic hypoxia is relatively small (12 mmHg). In the present study, we tested the hypothesis that perfusion with more viscous fluid (blood) will reveal more substantial effect of chronic hypoxia. METHODS: Using an isolated, dually perfused rat placenta perfused at a constant flow rate with homologous blood, perfusion pressure on the fetal side was measured. Then, the relationship between perfusion pressure and flow (P/Q) was determined. RESULTS: Fetoplacental vascular resistance was increased by chronic hypoxia (10 % O-2) during the last third of gestation. This was observed when the placentas were perfused with a low viscosity Krebs solution and more enhanced when perfused with blood. Nevertheless, we found no clear advantage for using blood instead of Krebs solution to study the effects of hypoxia on the fetoplacental vasculature. The elevation of fetoplacental vascular resistance caused by chronic hypoxia was at least partly resistant to acute reoxygenation. CONCLUSION: Using blood for the perfusion of the isolated rat placenta does not confer any clear methodological advantage over using Krebs solution (Tab. 2, Fig. 2, Ref. 21). Text in PDF www.elis.sk.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

—

Volume of the periodical

117

Issue of the periodical within the volume

10

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

583-586

UT code for WoS article

000387631100006

EID of the result in the Scopus database

2-s2.0-85014922999