Palonosetron compared with ondansetron in pediatric cancer patients: multicycle analysis of a randomized Phase III study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373664" target="_blank" >RIV/00216208:11130/17:10373664 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/17:10373664
Result on the web
<a href="https://doi.org/10.2217/fon-2017-0189" target="_blank" >https://doi.org/10.2217/fon-2017-0189</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/fon-2017-0189" target="_blank" >10.2217/fon-2017-0189</a>
Alternative languages
Result language
angličtina
Original language name
Palonosetron compared with ondansetron in pediatric cancer patients: multicycle analysis of a randomized Phase III study
Original language description
Aim: To investigate across multiple cycles the efficacy and safety of palonosetron in the prevention of chemotherapy-induced nausea and vomiting in pediatric cancer patients receiving highly or moderately emetogenic chemotherapy (HEC/MEC). Patients & methods: Patients were randomly assigned to 10, 20 mu g/kg palonosetron or 3 x 150 mu g/kg ondansetron for up to four cycles of HEC/MEC. Results: In all on-study chemotherapy cycles, complete response rates were higher in patients in the 20 mu g/kg palonosetron group than the ondansetron group. Treatment-emergent adverse events were comparable between the palonosetron 20 mu g/kg and ondansetron groups. Conclusion: Over four cycles of HEC/MEC, 20 mu g/kg palonosetron was an efficacious and safe treatment for the prevention of chemotherapy-induced nausea and vomiting in pediatric cancer patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Future Oncology
ISSN
1479-6694
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
1685-1698
UT code for WoS article
000409493600005
EID of the result in the Scopus database
2-s2.0-85028573236